[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease

MV Plikus, X Wang, S Sinha, E Forte, SM Thompson… - Cell, 2021 - cell.com
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Hair follicle immune privilege and its collapse in alopecia areata

M Bertolini, K McElwee, A Gilhar… - Experimental …, 2020 - Wiley Online Library
Anagen stage hair follicles (HFs) exhibit “immune privilege (IP)” from the level of the bulge
downwards to the bulb. Both passive and active IP mechanisms protect HFs from …

Advances in regenerative stem cell therapy in androgenic alopecia and hair loss: Wnt pathway, growth-factor, and mesenchymal stem cell signaling impact analysis …

P Gentile, S Garcovich - Cells, 2019 - mdpi.com
The use of stem cells has been reported to improve hair regrowth in several therapeutic
strategies, including reversing the pathological mechanisms, that contribute to hair loss …

A therapeutic microneedle patch made from hair-derived keratin for promoting hair regrowth

G Yang, Q Chen, D Wen, Z Chen, J Wang, G Chen… - Acs Nano, 2019 - ACS Publications
Activating hair follicle stem cells (HFSCs) to promote hair follicle regrowth holds promise for
hair loss therapy, while challenges still remain to develop a scenario that enables enhanced …

Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor

Z Liu, W Li, L Geng, L Sun, Q Wang, Y Yu, P Yan… - Cell discovery, 2022 - nature.com
Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?

C Gorzelanny, C Mess, SW Schneider, V Huck… - Pharmaceutics, 2020 - mdpi.com
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C (ut) annabinoid” System

KF Tóth, D Ádám, T Bíró, A Oláh - Molecules, 2019 - mdpi.com
The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted
homeostatic regulator, which influences a wide-variety of physiological processes all over …

Clonal dynamics in early human embryogenesis inferred from somatic mutation

S Park, NM Mali, R Kim, JW Choi, J Lee, J Lim, JM Park… - Nature, 2021 - nature.com
Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

Molecular mechanisms of hair growth and regeneration: current understanding and novel paradigms

KS Houschyar, MR Borrelli, C Tapking, D Popp… - Dermatology, 2020 - karger.com
Hair is a defining feature of mammals and has critical functions, including protection,
production of sebum, apocrine sweat and pheromones, social and sexual interactions …

The biology of human hair greying

JDB O'Sullivan, C Nicu, M Picard, J Chéret… - Biological …, 2021 - Wiley Online Library
Hair greying (canities) is one of the earliest, most visible ageing‐associated phenomena,
whose modulation by genetic, psychoemotional, oxidative, senescence‐associated …