Roles of follicular helper and regulatory T cells in allergic diseases and allergen immunotherapy
Allergic diseases are characterized by overactive type 2 immune responses to allergens and
immunoglobulin E (IgE)‐mediated hypersensitivity. Emerging evidence suggests that …
immunoglobulin E (IgE)‐mediated hypersensitivity. Emerging evidence suggests that …
T follicular helper cells in autoimmune diseases
X Wei, X Niu - Journal of Autoimmunity, 2023 - Elsevier
T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules
CXC motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting …
CXC motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting …
Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus
X Gao, Y Song, J Wu, S Lu, X Min, L Liu… - The Journal of …, 2022 - Am Soc Clin Investig
The trace element iron affects immune responses and vaccination, but knowledge of its role
in autoimmune diseases is limited. Expansion of pathogenic T cells, especially T follicular …
in autoimmune diseases is limited. Expansion of pathogenic T cells, especially T follicular …
Recent advances in understanding the genetic basis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a polygenic chronic autoimmune disease leading to
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
multiple organ damage. A large heritability of up to 66% is estimated in SLE, with roughly …
Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep
Genome-wide association studies (GWAS) in humans have identified loci robustly
associated with several heritable diseases or traits, yet little is known about the functional …
associated with several heritable diseases or traits, yet little is known about the functional …
Identification of 22 susceptibility loci associated with testicular germ cell tumors
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and
have a high heritability. In this study, the international Testicular Cancer Consortium …
have a high heritability. In this study, the international Testicular Cancer Consortium …
Biological constraints on GWAS SNPs at suggestive significance thresholds reveal additional BMI loci
To uncover novel significant association signals (p< 5× 10− 8), genome-wide association
studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction …
studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction …
Multi–cell type gene coexpression network analysis reveals coordinated interferon response and cross–cell type correlations in systemic lupus erythematosus
B Panwar, BJ Schmiedel, S Liang, B White… - Genome …, 2021 - genome.cshlp.org
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately
affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable …
affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable …
Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci
The germinal center (GC) response is critical for both effective adaptive immunity and
establishing peripheral tolerance by limiting autoreactive B cells. Dysfunction in these …
establishing peripheral tolerance by limiting autoreactive B cells. Dysfunction in these …
Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools
P Freire-Pritchett, H Ray-Jones, M Della Rosa… - Nature protocols, 2021 - nature.com
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions
involving, at least on one end, regions of interest such as gene promoters. Signal detection …
involving, at least on one end, regions of interest such as gene promoters. Signal detection …