The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration

S Grisanti, O Tatar - Progress in retinal and eye research, 2008 - Elsevier
Age-related macular degeneration (AMD) is a multifaceted disease characterized by early
subclinical changes at the choroidea–retinal pigment epithelium interface. Both the causal …

Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization

RE Hogg, JV Woodside, SECM Gilchrist, R Graydon… - Ophthalmology, 2008 - Elsevier
PURPOSE: To investigate the association of cardiovascular risk factors and inflammatory
markers with neovascular age-related macular degeneration (AMD). DESIGN: Cross …

Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization

K Izumi-Nagai, N Nagai, Y Ozawa, M Mihara… - The American journal of …, 2007 - Elsevier
Interleukin (IL)-6, a potent proinflammatory cytokine, is suggested to be a risk factor for
choroidal neovascularization (CNV) because of its increased levels in the serum of patients …

Verteporfin photodynamic therapy and anti-angiogenic drugs: potential for combination therapy in exudative age-related macular degeneration

PK Kaiser - Current medical research and opinion, 2007 - Taylor & Francis
Objective: To discuss the rationale for combining anti-angiogenic treatment with verteporfin
(Visudyne) photodynamic therapy in the management of choroidal neovascularization …

Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin

K Izumi-Nagai, N Nagai, K Ohgami… - … & visual science, 2008 - iovs.arvojournals.org
purpose. Astaxanthin (AST) is a carotenoid found in marine animals and vegetables. The
purpose of the present study was to investigate the effect of AST on the development of …

[HTML][HTML] Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

W Xia, C Li, Q Chen, J Huang, Z Zhao, P Liu… - … Pharmaceutica Sinica B, 2022 - Elsevier
Retinal pigment epithelial (RPE) is primarily impaired in age-related macular degeneration
(AMD), leading to progressive loss of photoreceptors and sometimes choroidal …

Angiotensin II type 1 receptor–mediated inflammation is required for choroidal neovascularization

N Nagai, Y Oike, K Izumi-Nagai, T Urano… - … , and vascular biology, 2006 - Am Heart Assoc
Background—Choroidal neovascularization (CNV) is a critical pathogenesis in age-related
macular degeneration, the most common cause of blindness in the developed countries …

[HTML][HTML] Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD)

S Nashine, P Cohen, J Wan, MC Kenney - Aging (Albany NY), 2022 - ncbi.nlm.nih.gov
Inflammation plays a crucial role in the etiology and pathogenesis of AMD (Age-related
Macular Degeneration). Humanin G (HNG) is a Mitochondrial Derived Peptide (MDP) that is …

Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy

R Klein, BEK Klein, MD Knudtson, TY Wong… - American journal of …, 2005 - Elsevier
PURPOSE: To examine the association of systemic markers of inflammatory disease and
endothelial dysfunction with age-related maculopathy (ARM). DESIGN:(1) Nested case …

[PDF][PDF] Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina

RF Mullins, JM Skeie, EA Malone, MH Kuehn - Mol Vis, 2006 - molvis.org
Purpose: In order to understand the extent of choriocapillary endothelial cell activation in
different topographic regions of the eye, we sought to compare the localization of …