The role of m6A modification in physiology and disease

C Yang, Y Hu, B Zhou, Y Bao, Z Li, C Gong… - Cell death & …, 2020 - nature.com
Similar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs
have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A) …

[HTML][HTML] Ghrelin

TD Müller, R Nogueiras, ML Andermann… - Molecular …, 2015 - Elsevier
Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

M Pigeyre, FT Yazdi, Y Kaur, D Meyre - Clinical science, 2016 - portlandpress.com
In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Epidemiology and determinants of type 2 diabetes in south Asia

AP Hills, R Arena, K Khunti, CS Yajnik… - The lancet Diabetes & …, 2018 - thelancet.com
Type 2 diabetes has rapidly developed into a major public health problem in south Asia
(defined here as Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka) in recent …

FTO–a common genetic basis for obesity and cancer

N Lan, Y Lu, Y Zhang, S Pu, H Xi, X Nie, J Liu… - Frontiers in …, 2020 - frontiersin.org
In recent years, the prevalence of obesity and cancer have been rising. Since this poses a
serious threat to human health, the relationship between the two has attracted much …

The bigger picture of FTO—the first GWAS-identified obesity gene

RJF Loos, GSH Yeo - Nature Reviews Endocrinology, 2014 - nature.com
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

[HTML][HTML] Molecular genetics of human obesity: A comprehensive review

RK Singh, P Kumar, K Mahalingam - Comptes rendus biologies, 2017 - Elsevier
Obesity and its related health complications is a major problem worldwide. Hypothalamus
and their signalling molecules play a critical role in the intervening and coordination with …

Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms

KD Corbin, KA Driscoll, RE Pratley, SR Smith… - Endocrine …, 2018 - academic.oup.com
There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

A link between FTO, ghrelin, and impaired brain food-cue responsivity

E Karra, OG O'Daly, AI Choudhury… - The Journal of …, 2013 - Am Soc Clin Investig
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with
human obesity and obesity-prone behaviors, including increased food intake and a …

Genetic susceptibility to type 2 diabetes and obesity: from genome-wide association studies to rare variants and beyond

N Grarup, CH Sandholt, T Hansen, O Pedersen - Diabetologia, 2014 - Springer
During the past 7 years, genome-wide association studies have shed light on the
contribution of common genomic variants to the genetic architecture of type 2 diabetes …