The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

Abstract γδ T cells are a unique and conserved population of lymphocytes that have been
the subject of a recent explosion of interest owing to their essential contributions to many …

Background γδ T cells are a distinct subgroup of T cells containing T cell receptors (TCRs) γ
and TCR δ chains with diverse structural and functional heterogeneity. As a bridge between …

Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …

IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

The tumor immune microenvironment contributes to tumor initiation, progression, and
response to therapy. Among the immune cell subsets that play a role in the tumor …

Abstract γδT cells are a conserved population of innate lymphocytes with diverse structural
and functional heterogeneity that participate in various immune responses during tumor …

The contributions of γδ T-cells to immunity to infection or tumors critically depend on their
activation and differentiation into effectors capable of secreting cytokines and killing infected …

There is increasing clinical evidence indicating that the immune system may either promote
or inhibit tumor progression. Several studies have demonstrated that tumors undergoing …

Follicular helper T cells (Tfh) are located within germinal centers of lymph nodes. Cognate
interaction between Tfh, B cells, and IL‐21 drives B cells to proliferate and differentiate into …