Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …

Cytokine storm syndrome (CSS) is a critical clinical condition induced by a cascade of
cytokine activation, characterized by overwhelming systemic inflammation …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation,
often associated with genetic defects of lymphocyte cytotoxicity. Though a distinctive …

Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …

Objective To assess the benefit of the recombinant human interleukin‐1 receptor antagonist
anakinra in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis …

Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm
leading to multiple organ dysfunction and high mortality. HLH is classified into familial …

Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process …