The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …

Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

The pathways involved in suppressing DNA replication stress and the associated DNA
damage are critical to maintaining genome integrity. The Mre11 complex is unique among …

Life as we know it, simply would not exist without DNA replication. All living organisms utilize
a complex machinery to duplicate their genomes and the central role in this machinery …

Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …

Radiotherapy is the primary treatment for patients with nasopharyngeal carcinoma (NPC),
and approximately 20% of patients experience treatment failure due to tumour …

ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …

Chromosomal instability (CIN) is a hallmark of cancer that drives tumour evolution. It is now
recognised that CIN in cancer leads to the constitutive production of misplaced DNA in the …

Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of
certain viruses by binding to viral mRNAs and repressing the translation and/or promoting …