Chemoresistance remains a major complication of cancer treatments. Recent data provide
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …

SNAI1, a zinc finger transcription factor, not only acts as the master regulator of epithelial-
mesenchymal transition (EMT) but also functions as a driver of cancer progression, including …

Although the immune checkpoint role of programmed death ligand 1 (PD-L1) has been
established and targeted in cancer immunotherapy, the tumor-intrinsic role of PD-L1 is less …

Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and
promotes metastasis. However, Snail protein is unstable and is quickly degraded through …

Background Exosomes released from decidual stromal cells (DSC-exos) play a crucial role
in facilitating the epithelial–mesenchymal transition (EMT) of trophoblasts and insufficient …

The receptor tyrosine kinase AXL promotes tumor progression, metastasis, and therapy
resistance through the induction of epithelial-mesenchymal transition (EMT). Here, we found …

Protein ubiquitination is one of the most crucial posttranslational modifications responsible
for regulating the stability and activity of proteins involved in homeostatic cellular function …

Abstract Purpose Transglutaminase (TG)-2 is a ubiquitous multi-functional protein
expressed in all living cells. The purpose of the current study was to investigate the role of …

Abstract mTOR complex 1 (mTORC1) positively regulates cell invasion and metastasis by
enhancing translation of Snail. A connection between mTOR complex 2 (mTORC2) and cell …

BC is the most commonly diagnosed cancer and the second leading cause of cancer death
among women worldwide. Cellular stress is a condition that leads to disrupted homeostasis …