T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …

Abstract FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and
homeostasis of the immune system. The molecular mechanisms underlying the stability …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Regulatory T (Treg) cells, possess a strategic role in the maintenance of immune
homeostasis, and their function has been closely linked to development of diverse …

The transcription factor Foxp3 controls the differentiation and function of regulatory T‐cells
(Treg). Studies in the past decades identified numerous Foxp3‐interacting protein partners …

Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …