Schizophrenia is characterized by profound cognitive deficits that are not alleviated by
currently available medications. Many of these cognitive deficits involve dysfunction of the …

Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

G protein-coupled receptors (GPCRs) are the target of hundreds of approved drugs.
Although these drugs were designed to target individual receptors, it is becoming …

Abstract The pro-opiomelanocortin (POMC)-expressing neurons of the hypothalamic arcuate
nucleus (ARC) are involved in the control of food intake and metabolic processes. It is …

The D1 dopamine receptor (D1R) has been implicated in numerous neuropsychiatric
disorders, and D1R-selective ligands have potential as therapeutic agents. Previous studies …

Background Dopamine receptors interact with other receptors to form heterooligomers. One
such complex, the D1-D2 heteromer, demonstrated in cultured striatal neurons and rat …

A role for the mesolimbic dopaminergic system in the pathophysiology of depression has
become increasingly evident. Specifically, brain-derived neurotrophic factor (BDNF) has …

It is now well-established that stress elicits brain-and body-wide changes in physiology and
has significant impacts on many aspects of health. The hypothalamic-pituitary-adrenal (HPA) …

Abstract Calcium ion (Ca2+) homeostasis is crucial for neuron function and
neurotransmission. This study focused on the actions mediated by the CB1 receptor (CB1R) …

Biased signaling is a concept that has arisen in the G protein-coupled receptor (GCPR)
research field, and holds promise for the development of new drug development strategies …