Introduction: Pulmonary drug delivery is a complex field of research combining physics
which drive aerosol transport and deposition and biology which underpins efficacy and …

Purpose Deposition characteristics of MDI and DPI aerosols were compared throughout the
conducting airways for the first time using a combination of in vitro experiments and a newly …

Background: In vitro–in vivo correlations (IVIVCs) are needed to relate in vitro test results for
deposition to mean data from clinical trials, as well as the extremes in a population. Because …

Background: A new in vitro test method for dry powder inhalers (DPIs) was recently found to
be predictive of the published in vivo results for Budelin Novolizer. The present study was …

While a number of studies have considered the dynamics of ambient or environmental
particles in the respiratory tract, far fewer have evaluated the transport and deposition of …

Enhanced excipient growth (EEG) is a newly proposed respiratory delivery strategy in which
submicrometer or nanometer particles composed of a drug and hygroscopic excipient are …

Objectives The objective of this study was to investigate the in-vitro particle-size growth of
combination drug and excipient submicrometer aerosols generated from a series of …

Purpose The objective of this study is to evaluate the effects of enhanced condensational
growth (ECG), as a novel inhalation drug delivery method, on nano-aerosol deposition in a …

The use of extrathoracic airway replicas in optimization of drug delivery to the lungs with
nebulizers, dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs) is …

In this study, a new computational fluid dynamics (CFD) modeling approach for
pharmaceutical aerosols is further developed by evaluating the effects of turbulence …