Although RAS was formerly considered undruggable, various agents that inhibit RAS or
specific RAS oncoproteins have now been developed. Indeed, the importance of directly …

How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …

Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key
genetic step that complements activation of KRAS in promoting the development and …

Pancreatic cancer is highly aggressive and lethal. Due to the lack of effective methods for
detecting the disease at an early stage, pancreatic cancer is frequently diagnosed late …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …

Cancer stem cells (CSCs) play a critical role in the initiation, progression and therapy
relapse of many cancers including non-small cell lung cancer (NSCLC). Here, we aimed to …

To delineate the mechanisms by which the ERK1 and ERK2 mitogen-activated protein
kinases support mutant KRAS–driven cancer growth, we determined the ERK-dependent …

Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal
adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of …

Background and objectives Pancreatic ductal adenocarcinoma (PDAC) is one of the
deadliest malignancies. An epigenetic-based synthetic lethal strategy provides a novel …

DNA damage in astronauts induced by cosmic radiation poses a major barrier to human
space exploration. Cellular responses and repair of the most lethal DNA double-strand …