An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy
The azole antifungal drugs are an important class of chemotherapeutic agents with broad-
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …
Leishmaniasis treatment: update of possibilities for drug repurposing
VV Andrade Neto, EF Cunha Junior, VS Faioes… - 2018 - arca.fiocruz.br
The leishmaniases represent a public health problem in under-developed countries and are
considered a neglected disease by the World Health Organization (WHO). They are cuased …
considered a neglected disease by the World Health Organization (WHO). They are cuased …
Targeting Ergosterol Biosynthesis in Leishmania donovani: Essentiality of Sterol 14alpha-demethylase
Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of
cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are …
cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are …
In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis
The search for new therapeutic agents from natural sources has been a constant for the
treatment of diseases such as leishmaniasis. Herein, in vitro and in vivo pharmacological …
treatment of diseases such as leishmaniasis. Herein, in vitro and in vivo pharmacological …
Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key …
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites.
Current chemotherapeutic options against the deadly disease have significant limitations …
Current chemotherapeutic options against the deadly disease have significant limitations …
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents
F Saccoliti, VN Madia, V Tudino, A De Leo… - Journal of Medicinal …, 2019 - ACS Publications
We have designed and synthesized a series of new imidazole-based compounds
structurally related to an antiprotozoal agent with nanomolar activity which we identified …
structurally related to an antiprotozoal agent with nanomolar activity which we identified …
Analogues of Marine Guanidine Alkaloids Are in Vitro Effective against Trypanosoma cruzi and Selectively Eliminate Leishmania (L.) infantum Intracellular …
LF Martins, JT Mesquita, EG Pinto… - Journal of natural …, 2016 - ACS Publications
Synthetic analogues of marine sponge guanidine alkaloids showed in vitro antiparasitic
activity against Leishmania (L.) infantum and Trypanosoma cruzi. Guanidines 10 and 11 …
activity against Leishmania (L.) infantum and Trypanosoma cruzi. Guanidines 10 and 11 …
In vitro antileishmanial activity of novel azoles (3-imidazolylflavanones) against promastigote and amastigote stages of Leishmania major
Leishmaniasis is a protozoan infectious disease widely distributed all around the world. First
line drugs including antimoniales are insufficient due to resistance in endemic areas and …
line drugs including antimoniales are insufficient due to resistance in endemic areas and …
[HTML][HTML] Seasonal persistence of faecal indicator organisms in soil following dairy slurry application to land by surface broadcasting and shallow injection
Dairy farming generates large volumes of liquid manure (slurry), which is ultimately recycled
to agricultural land as a valuable source of plant nutrients. Different methods of slurry …
to agricultural land as a valuable source of plant nutrients. Different methods of slurry …
Activity of imidazole compounds on Leishmania (L.) infantum chagasi: reactive oxygen species induced by econazole
JT Mesquita, TA da Costa-Silva, S Borborema… - Molecular and cellular …, 2014 - Springer
Drug repositioning has been considered a promising approach to discover novel treatments
against neglected diseases. Among the major protozoan diseases, leishmaniasis remains a …
against neglected diseases. Among the major protozoan diseases, leishmaniasis remains a …