Protein ubiquitination is an important post-translational modification mechanism, which
regulates protein stability and activity. The ubiquitination of proteins can be reversed by …

Osteoporosis is an ageing‐related disease, that has become a major public health problem
and its pathogenesis has not yet been fully elucidated. Substantial evidence suggests a …

Deubiquitinases (DUBs) are essential for bone remodeling by regulating the differentiation
of osteoblast and osteoclast. USP17 encodes for a deubiquitinating enzyme, specifically …

Stabilization of bone structure and function involves multiple cell-to-cell and molecular
interactions, in which the regulatory functions of post-translational modifications such as …

The progression of periodontitis, a bacteria‐driven inflammatory and bone‐destructive
disease, involves myriad cellular and molecular mechanisms. Protein regulation significantly …

Background Ubiquitin-specific peptidases (USPs), also known as deubiquitinating enzymes
(DUBs), play a crucial role in maintaining cellular homeostasis by selectively removing …

Ubiquitin-specific protease 5 (USP5) belongs to the ubiquitin-specific protease (USP) family,
which uniquely recognizes unanchored polyubiquitin chains to maintain the homeostasis of …

In the skeleton, osteoblasts and osteoclasts synchronize their activities to maintain bone
homeostasis and integrity. Investigating the molecular mechanisms governing bone …

Ubiquitination and deubiquitination are important mechanisms to maintain normal
physiological activities, and their disorders or imbalances can lead to various diseases. As a …

ABSTRACT EF24, a curcumin analog, exerts a potent antitumor effect on various cancers.
However, whether EF24 retards the progression of triple-negative breast cancer (TNBC) …