Role of epidermal growth factor receptor (EGFR) and its ligands in kidney inflammation and damage

S Rayego-Mateos, R Rodrigues-Diez… - Mediators of …, 2018 - Wiley Online Library
Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end‐stage renal disease. Although many studies have …

The endoplasmic reticulum stress and the unfolded protein response in kidney disease: Implications for vascular growth factors

CA Ricciardi, L Gnudi - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
Acute kidney injury (AKI) and chronic kidney disease (CKD) represent an important
challenge for healthcare providers. The identification of new biomarkers/pharmacological …

scAI: an unsupervised approach for the integrative analysis of parallel single-cell transcriptomic and epigenomic profiles

S Jin, L Zhang, Q Nie - Genome biology, 2020 - Springer
Simultaneous measurements of transcriptomic and epigenomic profiles in the same
individual cells provide an unprecedented opportunity to understand cell fates. However …

[HTML][HTML] Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with …

A El-Fiqi, N Mandakhbayar, SB Jo, JC Knowles… - Bioactive materials, 2021 - Elsevier
Therapeutic options are quite limited in clinics for the successful repair of
infected/degenerated tissues. Although the prevalent treatment is the complete removal of …

Single-cell profiling reveals transcriptional signatures and cell-cell crosstalk in anti-PLA2R positive idiopathic membranous nephropathy patients

J Xu, C Shen, W Lin, T Meng, JD Ooi… - Frontiers in …, 2021 - frontiersin.org
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the
kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) …

The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells

Z He, Q Fang, H Li, B Shao, Y Zhang, Y Zhang… - …, 2019 - Elsevier
The development of therapeutic interventions for hearing loss requires a detailed
understanding of the genes and proteins involved in hearing. The FOXG1 protein plays an …

[HTML][HTML] Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

SW Hung, M Gaetani, Y Li, Z Tan, X Zheng… - Journal of …, 2024 - Elsevier
Endometriosis is a common chronic gynecological disease with endometrial cell
implantation outside the uterus. Angiogenesis is a major pathophysiology in endometriosis …

Immunohistochemical features of epithelial-mesenchymal transition in feline oral squamous cell carcinoma

K Harris, HB Gelberg, M Kiupel… - Veterinary …, 2019 - journals.sagepub.com
Feline oral squamous cell carcinoma (FOSCC) is an aggressive malignancy with invasive
and metastatic behavior. It is poorly responsive to chemotherapy and radiation. Neoplastic …

The mineral dust-induced gene, mdig, regulates angiogenesis and lymphangiogenesis in lung adenocarcinoma by modulating the expression of VEGF-A/C/D via …

H Zhou, F Geng, Y Chen, J Du, X Zhang… - Oncology …, 2021 - spandidos-publications.com
Mineral dust‑induced gene (mdig) is a novel lung cancer‑related oncogene. The aim of this
study was to explore the effects of mdig on angiogenesis and lymphangiogenesis by …

Renal biology driven macro-and microscale design strategies for creating an artificial proximal tubule using fiber-based technologies

IJM Vermue, R Begum, M Castilho… - ACS Biomaterials …, 2021 - ACS Publications
Chronic kidney disease affects one in six people worldwide. Due to the scarcity of donor
kidneys and the complications associated with hemodialysis (HD), a cell-based bioartificial …