Management of Graves' ophthalmopathy: reality and perspectives

L Bartalena, A Pinchera, C Marcocci - Endocrine reviews, 2000 - academic.oup.com
Graves' ophthalmopathy is an debilitating disease impairing the quality of life of affected
individuals. Despite recent progress in the understanding of its pathogenesis, treatment is …

Pathogenesis of Graves' ophthalmopathy

RS Bahn, AE Heufelder - New England Journal of Medicine, 1993 - Mass Medical Soc
Ophthalmopathy is a potentially disfiguring and sight-threatening component of Graves'
disease. It is clinically evident in 25 to 50 percent of patients with Graves' hyperthyroidism …

Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids

V Wittamer, JD Franssen, M Vulcano… - The Journal of …, 2003 - rupress.org
Dendritic cells (DCs) and macrophages are professional antigen-presenting cells (APCs)
that play key roles in both innate and adaptive immunity. ChemR23 is an orphan G protein …

Current perspective on the pathogenesis of Graves' disease and ophthalmopathy

BS Prabhakar, RS Bahn, TJ Smith - Endocrine reviews, 2003 - academic.oup.com
Graves' disease (GD) is a very common autoimmune disorder of the thyroid in which
stimulatory antibodies bind to the thyrotropin receptor and activate glandular function …

Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity

SM McLachlan, B Rapoport - Endocrine reviews, 2014 - academic.oup.com
Thyroid autoimmunity involves loss of tolerance to thyroid proteins in genetically susceptible
individuals in association with environmental factors. In central tolerance, intrathymic …

The thyrotropin (TSH)-releasing hormone receptor: interaction with TSH and autoantibodies

B Rapoport, GD Chazenbalk, JC Jaume… - Endocrine …, 1998 - academic.oup.com
Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies* |
Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement Oxford Academic …

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy

Y Wang, TJ Smith - Investigative ophthalmology & visual …, 2014 - iovs.arvojournals.org
Graves' disease (GD) is a common autoimmune condition. At its core, stimulatory
autoantibodies are directed at the thyroid-stimulating hormone receptor (TSHR), resulting in …

Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity

V Wittamer, B Bondue, A Guillabert… - The Journal of …, 2005 - journals.aai.org
Dendritic cells and macrophages are professional APCs that play a central role in initiating
immune responses, linking innate and adaptive immunity. Chemerin is a novel …

Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease

S Costagliola, NG Morgenthaler… - The Journal of …, 1999 - academic.oup.com
Detection of autoantibodies to the TSH receptor (TSH-R) in Graves' disease has found
widespread use in clinical routine and is performed mostly by commercial RRAs measuring …

[HTML][HTML] Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor

G Smits, O Olatunbosun, A Delbaere… - … England Journal of …, 2003 - Mass Medical Soc
The overproduction of endogenous chorionic gonadotropin during pregnancy has been
associated with spontaneous ovarian hyperstimulation syndrome. Yet the syndrome has …