Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a
framework structure that holds myofibers and blood capillaries and nerves supplying the …

Duchenne muscular dystrophy (DMD) is a common fatal heritable myopathy, with
cardiorespiratory failure occurring by the third decade of life. There is no specific treatment …

Duchenne muscular dystrophy (DMD) is a chronic muscle disease characterized by poor
myogenesis and replacement of muscle by extracellular matrix. Despite the shared genetic …

Duchenne muscular dystrophy (DMD) is an X-linked, lethal muscle degenerative disease
caused by loss of dystrophin protein. DMD has no cure and few treatment options …

Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes
severe locomotor limitations and early death due in part to respiratory muscle failure. Given …

Abstract The C57BL/10ScSn-Dmd mdx/J (BL10-mdx) mouse has been the most commonly
used model for Duchenne muscular dystrophy (DMD) for decades. Their muscle dysfunction …

Ribozymes are small catalytic RNA sequences capable of nucleotide-specific self-cleavage
found widespread in nature. Ribozyme cleavage generates distinct 2′, 3′-phosphate and …

Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a
wide range of signals such as motor input, exercise, and disease. Small animal models have …

Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

In the sanctity of pure drug discovery, objective reasoning can become clouded when
pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into …