Most of the metabolic needs of erythrocytes are covered by glycolysis, the oxidative pentose
phosphate pathway and the glutathione cycle. Hereditary enzyme deficiencies of all these …

Targeting glycolysis has been considered therapeutically intractable owing to its essential
housekeeping role. However, the context-dependent requirement for individual glycolytic …

The mature red cell has no nucleus or organelles and therefore cannot synthesise pro-tein
or lipids. It is totally dependent on glycolysis to convert glucose into an energy source …

Phosphoglucose isomerase (PGI) is a multifunctional protein, which, inside the cell,
functions as a housekeeping enzyme of glycolysis and gluconeogenesis and, outside the …

Phosphohexose isomerase (PHI) is a member of the ectoenzyme/exoenzyme family and
plays a key role in both glycolysis and gluconeogenesis pathways. Upon secretion PHI acts …

Glucose-6-phosphate isomerase (GPI, EC 5.3. 1.9) is a dimeric enzyme that catalyzes the
reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second …

Abstract Glucose-6-phosphate isomerase (GPI) deficiency, a genetic disorder responsible
for chronic nonspherocytic hemolytic anemia, is the second most common red blood cell …

Background Erythrocyte pyruvate kinase deficiency (PK deficiency) is an inherited hemolytic
anemia that has been documented in the Abyssinian and Somali breeds as well as random …

Glucose-6-phosphate isomerase (GPI), a homodimeric enzyme, catalyzes the
interconversion between glucose-6-phosphate and fructose-6-phosphate. In mammals, it …

Glucose-6-phosphate isomerase (GPI, EC 5.3. 1.9) is a dimeric enzyme that catalyzes the
reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second …