Proteolytic cleavage regulates numerous processes in health and disease. One key player
is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Guanylate-binding proteins (GBPs) have recently emerged as central orchestrators of
immunity to infection, inflammation, and neoplastic diseases. Within numerous host cell …

Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

Human embryonic stem cells (hESCs) provide opportunities for cell replacement therapy of
insulin-dependent diabetes. Therapeutic quantities of human stem cell-derived islets (SC …

Type I interferons (IFNs) facilitate cancer immunosurveillance, antitumor immunity and
antitumor efficacy of conventional cell death-inducing therapies (chemotherapy/radiotherapy …

Abstract Guanylate-binding protein 2 (GBP2) is an interferon-inducible large GTPase which
is crucial to the protective immunity against microorganisms. However, its biological function …

Glioblastoma is the most common malignant brain cancer with dismal survival and
prognosis. Temozolomide (TMZ) is a first-line chemotherapeutic agent for glioblastoma, but …

Methods Unsupervised clustering was employed to classify immune class and non-immune
class in 1424 pMMR/MSS patients from six independent public datasets. This binary …

Abstract Stanniocalcin-1 (STC1) is a secreted glycoprotein implicated in several pathologies
including retinal degeneration, cerebral ischemia, angiogenesis and inflammation. Aberrant …