Antibiofilm activity of host defence peptides: complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

T Li, Z Wang, J Guo, C de la Fuente-Nunez… - Science of The Total …, 2023 - Elsevier
The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides

DI Andersson, D Hughes… - Drug Resistance Updates, 2016 - Elsevier
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …

Disease manifestations and pathogenic mechanisms of group A Streptococcus

MJ Walker, TC Barnett, JD McArthur… - Clinical microbiology …, 2014 - Am Soc Microbiol
Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Wall teichoic acids of gram-positive bacteria

S Brown, JP Santa Maria Jr… - Annual review of …, 2013 - annualreviews.org
The peptidoglycan layers of many gram-positive bacteria are densely functionalized with
anionic glycopolymers known as wall teichoic acids (WTAs). These polymers play crucial …

Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

F Guilhelmelli, N Vilela, P Albuquerque… - Frontiers in …, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such
as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can …

Envelope structures of Gram-positive bacteria

M Rajagopal, S Walker - Protein and sugar export and assembly in Gram …, 2017 - Springer
Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Lipoteichoic acid synthesis and function in gram-positive bacteria

MG Percy, A Gründling - Annual review of microbiology, 2014 - annualreviews.org
Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

Y Lai, RL Gallo - Trends in immunology, 2009 - cell.com
Antimicrobial peptides (AMPs) are widely expressed and rapidly induced at epithelial
surfaces to repel assault from diverse infectious agents including bacteria, viruses, fungi and …

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

RM Corrigan, JC Abbott, H Burhenne, V Kaever… - PLoS …, 2011 - journals.plos.org
The cell wall is a vital and multi-functional part of bacterial cells. For Staphylococcus aureus,
an important human bacterial pathogen, surface proteins and cell wall polymers are …