The impact of carboxylesterases in drug metabolism and pharmacokinetics
L Di - Current drug metabolism, 2019 - ingentaconnect.com
Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …
Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I. Pharmacokinetics and clinical …
J Schüttler, A Eisenried, M Lerch, J Fechner… - …, 2020 - ingentaconnect.com
Background: Remimazolam (CNS 7056) is a new ultra–short-acting benzodiazepine for
intravenous sedation and anesthesia. Its pharmacokinetics and pharmacodynamics have …
intravenous sedation and anesthesia. Its pharmacokinetics and pharmacodynamics have …
Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CLpro: Inhibition potentials, covalent binding sites and inhibitory mechanisms
Y Xiong, GH Zhu, YN Zhang, Q Hu, HN Wang… - International Journal of …, 2021 - Elsevier
Abstract Coronavirus 3C-like protease (3CL pro) is a crucial target for treating coronavirus
diseases including COVID-19. Our preliminary screening showed that Ampelopsis …
diseases including COVID-19. Our preliminary screening showed that Ampelopsis …
Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper
Quantitative translation of information on drug absorption, disposition, receptor engagement,
and drug–drug interactions from bench to bedside requires models informed by …
and drug–drug interactions from bench to bedside requires models informed by …
Age‐and genotype‐dependent variability in the protein abundance and activity of six major uridine diphosphate‐glucuronosyltransferases in human liver
DK Bhatt, A Mehrotra, A Gaedigk… - Clinical …, 2019 - Wiley Online Library
The ontogeny of hepatic uridine diphosphate‐glucuronosyltransferases (UGTs) was
investigated by determining their protein abundance in human liver microsomes isolated …
investigated by determining their protein abundance in human liver microsomes isolated …
[HTML][HTML] Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine
L Ye, S Fan, P Zhao, C Wu, M Liu, S Hu, P Wang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. Effective treatments against …
syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. Effective treatments against …
Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics
Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …