Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Brains contain networks of interconnected neurons and so knowing the network architecture
is essential for understanding brain function. We therefore mapped the synaptic-resolution …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …

Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

The spinal dorsal horn is a major site for the induction and maintenance of mechanical
allodynia, but the circuitry that underlies this clinically important form of pain remains …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …