The increase in incidences of pediatric Crohn's Disease (CD) worldwide has been strongly
linked with dietary shifts towards a Westernized diet, ultimately leading to altered gut …

Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the
mechanisms governing their expression on human T cells have not been elucidated. In the …

The immune system and environmental factors are involved in various diseases, such as
inflammatory bowel disease (IBD), through their effect on genetics, which modulates …

The notion that neutrophils exist as a homogeneous population is being replaced with the
knowledge that neutrophils adopt different functional states. Neutrophils can have a pro …

Histone deacetylases (HDACs) and bromodomain-containing proteins (BCPs) play a key
role in chromatin remodeling. Based on their ability to regulate inducible gene expression in …

SP140, a lymphocytic-restricted protein, is an epigenetic reader working as a corepressor of
genes implicated in inflammation and orchestrating macrophage transcriptional programs to …

Abstract Speckled Protein 140 (SP140) is a chromatin reader with critical roles regulating
immune cell transcriptional programs, and SP140 splice variants are associated with …

SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS
studies have shown an association between SP140 single nucleotide polymorphisms …

Understanding the functions of human transcriptional regulatory genes SP110 and SP140
during Mycobacterium tuberculosis infection is crucial; in a mouse model, homologous …

克罗恩病(Crohn'sdisease, CD) 是一种自身免疫性炎症性肠道疾病, 病变可累及整个胃肠道.
营养疗法作为近年来治疗CD 的一种有效方式, 可通过调节机体代谢, 减少炎症反应 …