Lymphoid cells play a critical role in the immune system, which includes three subgroups of
T, B, and NK cells. Recognition of the complexity of the human genetics transcriptome in …

The coding regions account for only a small part of the human genome, and the remaining
vast majority of the regions generate large amounts of non-coding RNAs. Although non …

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy resulting
from overproduction of immature T-cells in the thymus and is typified by widespread …

Recombination activating genes (RAGs), consisting of RAG1 and RAG2, are stringently
regulated lymphoid-specific genes, which initiate V (D) J recombination in developing …

Cancer cells display DNA hypermethylation at specific CpG islands in comparison with their
normal healthy counterparts, but the mechanism that drives this so-called CpG island …

Genome-wide analyses in the last decade have uncovered the presence of a large number
of long non-protein-coding transcripts that show highly tissue-and state-specific expression …

RNA-binding proteins (RBP) have emerged as essential regulators that control gene
expression and modulate multiple cancer traits. T-cell acute lymphoblastic leukemia (T-ALL) …

The bromodomain and extraterminal (BET) family of proteins show altered expression
across various cancers. The members of the bromodomain (BRD) family contain epigenetic …

Abstract β‐Catenin/CTNNB1 is critical for leukemia initiation or the stem cell capacity of
several hematological malignancies. This review focuses on a general evaluation of β …

The stringent regulation of RAGs (Recombination activating genes), the site-specific
endonuclease responsible for V (D) J recombination, is important to prevent genomic …