RNase III Dicer produces small RNAs guiding sequence‐specific regulations, with important
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …

The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity
that restricts viral replication and propagation. As one of the four eIF2α kinases that sense …

Abstract Adenosine-to-inosine (A-to-I) editing of eukaryotic cellular RNAs is essential for
protection against auto-immune disorders. Editing is carried out by ADAR1, whose innate …

Abstract The Serine–Glycine–One-Carbon (SGOC) pathway is pivotal in multiple anabolic
processes. Expression levels of SGOC genes are deregulated under tumorigenic conditions …

Vascular endothelial growth factor A (VEGF-A), a fundamental component of angiogenesis,
provides nutrients and oxygen to solid tumors, and enhances tumor cell survival, invasion …

Although the route to generate microRNAs (miRNAs) is often depicted as a linear series of
sequential and constitutive cleavages, we now appreciate multiple alternative pathways as …

Adenosine-to-inosine editing is catalyzed by adenosine deaminases acting on RNA
(ADARs) in double-stranded RNA (dsRNA) regions. Although three ADARs exist in …

Background Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional
process related to a multitude of cellular and molecular activities. However, systematic …

The accurate cleavage of pre‐micro (mi) RNA s by Dicer and mi/si RNA guide strand
selection are important steps in forming the RNA‐induced silencing complex (RISC). The …

Deamination of adenosine in RNA to form inosine has wide ranging consequences on RNA
function including amino acid substitution to give proteins not encoded in the genome. What …