Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Transposable Elements (TE) are mobile DNA elements that can replicate and insert
themselves into different locations within the host genome. Their propensity to self …

Cells undergo a major epigenome reconfiguration when reprogrammed to human induced
pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human …

Transposable elements (TEs) drive genome evolution and are a notable source of
pathogenesis, including cancer. While CpG methylation regulates TE activity, the locus …

Diverse inbred mouse strains are important biomedical research models, yet genome
characterization of many strains is fundamentally lacking in comparison with humans. In …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Mice harbor∼ 2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1).
The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity …

Retrotransposons are mobile DNA sequences duplicated via transcription and reverse
transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons …

Epigenetic silencing defends against LINE-1 (L1) retrotransposition in mammalian cells.
However, the mechanisms that repress young L1 families and how L1 escapes to cause …

Summary Long interspersed element 1 (L1) retrotransposons are implicated in human
disease and evolution. Their global activity is repressed by DNA methylation, but …