Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

KCNQ1 is the pore-forming subunit of cardiac slow-delayed rectifier potassium (I Ks)
channels. Mutations in the kcnq1 gene are the leading cause of congenital long QT …

Background—Life-threatening disorders of heart rhythm may arise during infancy and can
result in the sudden and tragic death of a child. We performed exome sequencing on 2 …

Voltage-dependent ion channels underlie the propagation of action potentials and other
forms of electrical activity in cells. In these proteins, voltage sensor domains (VSDs) regulate …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Abstract Calcium (Ca2+) is the central second messenger in the translation of electrical
signals into mechanical activity of the heart. This highly coordinated process, termed …

Triggered activity in cardiac muscle and intracellular Ca2+ have been linked in the past.
However, today not only are there a number of cellular proteins that show clear Ca2+ …

Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …