The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …

The mammalian kidney, which at maturity contains thousands of nephrons joined to a highly
branched collecting duct (CD) system, is an important model system for studying the …

The mammalian kidney is composed of thousands of individual epithelial tubules known as
nephrons. Deficits in nephron number are associated with myriad diseases ranging from …

Present models suggest that the fate of the kidney epithelial progenitors is solely regulated
by signals from the adjacent ureteric bud. The bud provides signals that regulate the …

Constitutive Wnt signalling is characterized by excessive levels of β-catenin protein and is a
frequent occurrence in cancer. APC and Axin are key components of the β-catenin …

Abstract Background The Poly (ADP-ribose) polymerase (PARP) superfamily was originally
identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins …

Porcupine is a member of the membrane-bound O-acyltransferase family of proteins. It
catalyzes the palmitoylation of Wnt proteins, a process required for their secretion and …

Background New pharmacologic targets are urgently needed to treat or prevent lung cancer,
the most common cause of cancer death for men and women. This study identified one such …

Within the developing mammalian kidney, several populations of progenitors form the
discrete cellular components of the final organ. Fate mapping experiments revealed the cap …

Tankyrases are the group of enzymes belonging to a class of Poly (ADP-ribose) polymerase
(PARP) recently named ADP-ribosyltransferase (ARTD). The two isoforms of tankyrase ie …