Obesity is a worldwide multifactorial disease caused by an imbalance in energy metabolism,
increasing adiposity, weight gain, and promoting related diseases such as diabetes …

Introduction The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy
transduction mechanisms and mitochondrial activities awaits deeper investigations. Our …

Loss-of-function mutations of the PINK1 kinase cause familial early-onset Parkinson's
disease (PD). PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin …

Mitochondrial dysfunction is thought to be central to the pathophysiology of Parkinson's
disease. The preferential vulnerability of dopaminergic (DA) neurons of the substantia nigra …

Mitochondrial morphology is a key indicator of cellular health and function. It is primarily
regulated by the post-translational modifications of the dynamin family GTPase proteins …

While mitochondria contain their own genome, more than 99% of mitochondrial proteins are
nuclear-encoded, synthesized in the cytosol, and rely on mitochondrial targeting sequences …

Background: Mitochondrial diseases (MDs) are a group of genetic disorders with diverse
patient phenotypes resulting from mitochondrial dysfunction. Pathologies are often poorly …

Loss-of-function mutations of the PINK1 kinase cause familial early-onset Parkinson's
disease (PD). PINK1 is activated upon mitochondrial damage to phosphorylate Ubiquitin …