Liver diseases represent a significant global health challenge, thereby necessitating
extensive research to understand their intricate complexities and to develop effective …

The adult liver of most vertebrates is predominantly comprised of hepatocytes. However,
these cells must work in concert with biliary, stellate, vascular, and immune cells to …

X-linked myotubular myopathy (XLMTM) is a fatal congenital disorder caused by mutations
in the MTM1 gene. Currently, there are no approved treatments, although AAV8-mediated …

In contrast to mice, zebrafish have an exceptional yet elusive ability to replenish lost β cells
in adulthood. Understanding this framework would provide mechanistic insights for β cell …

In Japan, bezafibrate (BF) is a second‐line agent for primary biliary cholangitis (PBC) that is
refractory to ursodeoxycholic acid (UDCA) treatment. From a retrospective cohort (n= 873) …

Background Mononuclear cell infiltration of exocrine glands, production of Ro/SSA and
La/SSB autoantibodies, along with oral and ocular dryness, are characteristic features of …

Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown
etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest …

The presence of cirrhosis increases the mortality of patients with peptic ulcer bleeding
(PUB). Both acute variceal bleeding (AVB) and PUB are associated with substantial mortality …

Resident microbes promote many aspects of host development, although the mechanisms
by which microbiota influence host tissues remain unclear. We showed previously that the …

The liver is a highly regenerative organ, yet the presence of a dedicated stem cell population
remains controversial. Here, we interrogate a severe hepatocyte injury model in adult …