Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …

Degradation of tissue proteins is controlled by multiple means. These include regulation of
the synthesis of proteinases, activation of the zymogen forms, the activity of the mature …

Wound repair involves cell migration and tissue remodeling, and these ordered and
regulated processes are facilitated by matrix-degrading proteases. We reported that …

Objective To correlate the increased collagenase production previously seen in
chondrocytes isolated from osteoarthritic (OA) lesions and the expression of cytokines and …

The tenn tissue remodeling describes transient or pennanent changes in tissue architecture
that involve breaching of histological barriers such as basement membranes, basal laminae …

We have previously described decreased immunostaining of nidogen-1/entactin; laminin
chains α1, α5, β1, γ1; and epithelial integrin α3β1 in human diabetic retinopathy (DR) …

Matrix metalloproteinases (MMPs) play a critical role in bone remodeling and tumor
spreading. Multiple myeloma (MM) is a plasma cell malignancy primarily localized within the …

Genome-wide DNA hypomethylation is a critical mechanism underlying neoplastic
transformation. Thus, genes that are suppressed in normal tissues or in specific cell types …

purpose. The cytokines TNF and IL-1 mediate the MMP-3 increase that occurs in response
to trabecular meshwork (TM) treatment by laser trabeculoplasty. This MMP-3 increase …

We investigated the role of tetracycline in the transcriptional regulation of matrix
metalloproteinases. Using interleukin‐1β (IL‐1) induced stromelysin as a model system, we …