A guide to chemokines and their receptors

CE Hughes, RJB Nibbs - The FEBS journal, 2018 - Wiley Online Library
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

R Alon, M Sportiello, S Kozlovski, A Kumar… - Nature Reviews …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes …

Inflammation and lymphatic function

S Schwager, M Detmar - Frontiers in immunology, 2019 - frontiersin.org
The lymphatic vasculature plays a crucial role in regulating the inflammatory response by
influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes …

Resolution of inflammation: an integrated view

A Ortega‐Gómez, M Perretti… - EMBO molecular …, 2013 - embopress.org
Resolution of inflammation is a coordinated and active process aimed at restoration of tissue
integrity and function. This review integrates the key molecular and cellular mechanisms of …

Regulation of the inflammatory response in cardiac repair

NG Frangogiannis - Circulation research, 2012 - Am Heart Assoc
Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …

Pathophysiology of myocardial infarction

NG Frangogiannis - Comprehensive Physiology, 2011 - Wiley Online Library
Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Is resolution the end of inflammation?

KT Feehan, DW Gilroy - Trends in molecular medicine, 2019 - cell.com
Deciphering the origins of chronic inflammatory and autoimmune diseases remains elusive
with reliance on therapies aimed at halting inflammation in its tracks. In recent years, an …

Mechanisms of regulation of the chemokine-receptor network

MJ Stone, JA Hayward, C Huang, Z E. Huma… - International journal of …, 2017 - mdpi.com
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

Mediators of the resolution of the inflammatory response

MA Sugimoto, JP Vago, M Perretti, MM Teixeira - Trends in immunology, 2019 - cell.com
The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …

Immune regulation by atypical chemokine receptors

RJB Nibbs, GJ Graham - Nature Reviews Immunology, 2013 - nature.com
Chemokines have fundamental roles in regulating immune and inflammatory responses,
primarily through their control of leukocyte migration and localization. The biological …