Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis

AV Ivanov, VT Valuev-Elliston, DA Tyurina… - …, 2016 - pmc.ncbi.nlm.nih.gov
Virally induced liver cancer usually evolves over long periods of time in the context of a
strongly oxidative microenvironment, characterized by chronic liver inflammation and …

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

R Domitrović, I Potočnjak - Archives of toxicology, 2016 - Springer
Hepatoprotective effects of natural compounds have been frequently attributed to their
antioxidant properties and the ability to mobilize endogenous antioxidant defense system …

Hepatitis B virus deregulates the cell cycle to promote viral replication and a premalignant phenotype

Y Xia, X Cheng, Y Li, K Valdez, W Chen… - Journal of …, 2018 - Am Soc Microbiol
Hepatitis B virus (HBV) infection is a major health problem worldwide, and chronically
infected individuals are at high risk of developing cirrhosis and hepatocellular carcinoma …

Effect of hepatitis viruses on the Nrf2/Keap1-signaling pathway and its impact on viral replication and pathogenesis

D Bender, E Hildt - International journal of molecular sciences, 2019 - mdpi.com
With respect to their genome and their structure, the human hepatitis B virus (HBV) and
hepatitis C virus (HCV) are complete different viruses. However, both viruses can cause an …

Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation

J Ahodantin, M Bou-Nader, C Cordier, J Mégret… - Oncogene, 2019 - nature.com
Hepatitis B virus X protein (HBx) contributes to Hepatitis B virus (HBV)-related liver cancer.
However, its impact on hepatocyte proliferation and genomic stability remains elusive. We …

Chronic hepatitis B virus infection associated with increased colorectal cancer risk in Taiwanese population

FH Su, TN Le, CH Muo, SA Te, FC Sung, CC Yeh - Viruses, 2020 - mdpi.com
Chronic hepatitis B virus (HBV) infections and colorectal cancer (CRC) are prevalent in
Taiwan. We carried out a population-based case-control study to assess the association …

Identification of key genes associated with the process of hepatitis B inflammation and cancer transformation by integrated bioinformatics analysis

J Zhang, X Liu, W Zhou, S Lu, C Wu, Z Wu, R Liu… - Frontiers in …, 2021 - frontiersin.org
Background Hepatocellular carcinoma (HCC) has become the main cause of cancer death
worldwide. More than half of hepatocellular carcinoma developed from hepatitis B virus …

ATM and ATR expression potentiates HBV replication and contributes to reactivation of HBV infection upon DNA damage

A Kostyusheva, S Brezgin, E Bayurova, I Gordeychuk… - Viruses, 2019 - mdpi.com
Chronic hepatitis B virus infection (CHB) caused by the hepatitis B virus (HBV) is one of the
most common viral infections in the world. Reactivation of HBV infection is a life-threatening …

Proteasomal activator 28 gamma stabilizes hepatitis B virus X protein by competitively inhibiting the Siah-1-mediated proteasomal degradation

J Han, H Kim, H Jeong, H Yoon, KL Jang - Biochemical and Biophysical …, 2021 - Elsevier
Proteasomal activator 28 gamma (PA28γ) upregulates the levels of HBx, a regulatory protein
of hepatitis B virus (HBV) to stimulate HBV replication; however, the detailed mechanism …

Hepatitis B virus X protein activates proteasomal activator 28 gamma expression via upregulation of p53 levels to stimulate virus replication

S Yeom, H Jeong, SS Kim… - Journal of General …, 2018 - microbiologyresearch.org
Proteasomal activator gamma (PA28γ), frequently overexpressed in hepatocellular
carcinoma, is believed to play important roles in tumourigenesis. However, the underlying …