Importance According to National Health and Nutrition Examination Survey data, 52% of
surveyed US adults reported using at least 1 dietary supplement in the prior 30 days and …

Importance Cardiovascular disease and cancer are the 2 leading causes of death in the US,
and vitamin and mineral supplementation has been proposed to help prevent these …

Colorectal cancer (CRC) is one of the most common malignancies in the United States.
Every 3 years, the American Cancer Society provides an update of CRC incidence, survival …

Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

Colorectal cancer is the third most common cancer and the third leading cause of cancer
death in men and women in the United States. This article provides an overview of colorectal …

Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Folate, an essential nutrient found naturally in foods in a reduced form, is present in dietary
supplements and fortified foods in an oxidized synthetic form (folic acid). There is …

Diet has an important role in the development of colorectal cancer. In the past few decades,
findings from extensive epidemiologic and experimental investigations have linked …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

The authors identified individual randomized controlled trials from previous meta-analyses
and additional searches, and then performed meta-analyses on cardiovascular disease …