Genetic and epigenetic basis of hepatoblastoma diversity

G Nagae, S Yamamoto, M Fujita, T Fujita… - Nature …, 2021 - nature.com
Hepatoblastoma (HB) is the most common pediatric liver malignancy; however, hereditary
predisposition and acquired molecular aberrations related to HB clinicopathological …

[PDF][PDF] Liver tumors in pediatric patients

R Meyers, E Hiyama, P Czauderna, GM Tiao - Surgical Oncology Clinics of …, 2021 - Elsevier
In contrast with adults, about two-thirds of hepatic tumors in children are malignant. The
2014 international consensus classification of pediatric liver tumors is shown in Box 1 …

Current Approaches in Hepatoblastoma—New Biological Insights to Inform Therapy

PV Wu, A Rangaswami - Current Oncology Reports, 2022 - Springer
Abstract Purpose of Review As the most common pediatric primary liver cancer with rising
incidence, hepatoblastoma remains challenging to treat. Here, we review the current …

Incidence and 5‐year survival of children and adolescents with hepatoblastoma in the United States

JA Kahla, DA Siegel, S Dai, PJ Lupo… - Pediatric blood & …, 2022 - Wiley Online Library
Objective Hepatoblastoma (HB) is the most common pediatric primary malignant liver tumor,
its incidence has been increasing worldwide, but recent changes in incidence and outcomes …

SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration

K Eloranta, M Pihlajoki, E Liljeström… - Frontiers in …, 2023 - frontiersin.org
Background In response to hypoxia, tumor cells undergo transcriptional reprogramming
including upregulation of carbonic anhydrase (CA) IX, a metalloenzyme that maintains acid …

[HTML][HTML] Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults

P Sumazin, TL Peters, SF Sarabia, HR Kim… - Journal of …, 2022 - Elsevier
Background & Aims Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the
predominant liver cancers in children, though their respective treatment options and …

Surgical management of liver tumors

KJ Riehle, SA Vasudevan, A Bondoc… - Pediatric blood & …, 2024 - Wiley Online Library
Two percent of pediatric malignancies arise primarily in the liver; roughly 60% of these
cancers are hepatoblastoma (HB). Despite the rarity of these cases, international …

Children's Oncology Group's 2023 blueprint for research: Liver tumors

AF O'Neill, RL Meyers, HM Katzenstein… - Pediatric Blood & …, 2023 - Wiley Online Library
Liver tumors account for approximately 1%–2% of all pediatric malignancies, with the two
most common tumors being hepatoblastoma (HB) and hepatocellular carcinoma (HCC) …

Outcomes of patients treated for hepatoblastoma with low alpha-fetoprotein and/or small cell undifferentiated histology: a report from the Children's Hepatic Tumors …

AD Trobaugh-Lotrario, R Maibach, DC Aronson… - Cancers, 2023 - mdpi.com
Simple Summary Hepatoblastoma is the most common malignant liver tumor in children.
Small cell undifferentiated histology and low alpha-fetoprotein have been previously …

Factors influencing recurrence after complete remission in children with hepatoblastoma: A 14-year retrospective study in China

F Li, W Zhang, H Hu, X Zhu, Y Zhang, D Huang - PLoS One, 2021 - journals.plos.org
Objective After a complete remission to treatment for hepatoblastoma, some children still
have recurrence. We identified and explored the factors that influence recurrence after …