[HTML][HTML] Quantitative non-targeted analysis: bridging the gap between contaminant discovery and risk characterization
Chemical risk assessments follow a long-standing paradigm that integrates hazard, dose–
response, and exposure information to facilitate quantitative risk characterization. Targeted …
response, and exposure information to facilitate quantitative risk characterization. Targeted …
High-resolution mass spectrometry for human exposomics: Expanding chemical space coverage
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …
between genetic drivers and disease outcomes. High-resolution mass spectrometry …
Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism
Glioblastoma is the most lethal primary brain tumor with glioblastoma stem cells (GSCs) atop
a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive …
a cellular hierarchy. GSCs often reside in a perivascular niche, where they receive …
A novel workflow for semi-quantification of emerging contaminants in environmental samples analyzed by LC-HRMS
R Aalizadeh, V Nikolopoulou, N Alygizakis… - Analytical and …, 2022 - Springer
There is an increasing need for developing a strategy to quantify the newly identified
substances in environmental samples, where there are not always reference standards …
substances in environmental samples, where there are not always reference standards …
Addressing big data challenges in mass spectrometry-based metabolomics
Advancements in computer science and software engineering have greatly facilitated mass
spectrometry (MS)-based untargeted metabolomics. Nowadays, gigabytes of metabolomics …
spectrometry (MS)-based untargeted metabolomics. Nowadays, gigabytes of metabolomics …
TrendProbe: time profile analysis of emerging contaminants by LC-HRMS non-target screening and deep learning convolutional neural network
V Nikolopoulou, R Aalizadeh, MC Nika… - Journal of Hazardous …, 2022 - Elsevier
Peak prioritization is one of the key steps in non-target screening of environmental samples
to direct the identification efforts to relevant and important features. Occurrence of chemicals …
to direct the identification efforts to relevant and important features. Occurrence of chemicals …
Quantitative challenges and their bioinformatic solutions in mass spectrometry-based metabolomics
Improving the quantitative performance of mass spectrometry (MS)-based metabolomics is
the key to its successful application in a broad range of research questions. Like other …
the key to its successful application in a broad range of research questions. Like other …
Representing the metabolome with high fidelity: range and response as quality control factors in LC-MS-based global profiling
Liquid chromatography–mass spectrometry (LC-MS) is a powerful and widely used
technique for measuring the abundance of chemical species in living systems. Its sensitivity …
technique for measuring the abundance of chemical species in living systems. Its sensitivity …
Quantification of chemicals in non-targeted analysis without analytical standards–Understanding the mechanism of electrospray ionization and making predictions
TA Johnson, DP Abrahamsson - Current Opinion in Environmental Science …, 2024 - Elsevier
The constant creation and release of new chemicals to the environment is forming an ever-
widening gap between available analytical standards and known chemicals. Developing …
widening gap between available analytical standards and known chemicals. Developing …
Surviving in the Brine: A Multi-Omics Approach for Understanding the Physiology of the Halophile Fungus Aspergillus sydowii at Saturated NaCl Concentration
I Jiménez-Gómez, G Valdés-Muñoz… - Frontiers in …, 2022 - frontiersin.org
Although various studies have investigated osmoadaptations of halophilic fungi to saline
conditions, only few analyzed the fungal mechanisms occurring at saturated NaCl …
conditions, only few analyzed the fungal mechanisms occurring at saturated NaCl …