DNA damage and repair in individual cells: applications of the comet assay in radiobiology

PL Olive - International journal of radiation biology, 1999 - Taylor & Francis
The comet assay is a single-cell gel electrophoresis method that can measure a variety of
types of DNA damage, and repair of damage, in individual cells. It is now in widespread use …

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing

RR Tice, E Agurell, D Anderson… - Environmental and …, 2000 - Wiley Online Library
Abstract Atthe International Workshop on Genotoxicity Test Procedures (IWGTP) held in
Washington, DC, March 25–26, 1999, an expert panel met to develop guidelines for the use …

Recommendations for conducting the in vivo alkaline Comet assay

A Hartmann, E Agurell, C Beevers… - …, 2003 - academic.oup.com
The in vivo alkaline single cell gel electrophoresis assay, hereafter the Comet assay, can be
used to investigate the genotoxicity of industrial chemicals, biocides, agrochemicals and …

Ultrasonic-activated micellar drug delivery for cancer treatment

GA Husseini, WG Pitt - Journal of pharmaceutical sciences, 2009 - Elsevier
The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have
been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that …

Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa

ET Donnelly, M O'Connell, N McClure… - Human …, 2000 - academic.oup.com
Sperm DNA integrity is essential for accurate transmission of genetic material to offspring.
Fragmentation of genomic DNA is an initial hallmark of apoptosis (programmed cell death) …

Chemical analysis and genotoxicological safety assessment of paper and paperboard used for food packaging

A Ozaki, Y Yamaguchi, T Fujita, K Kuroda… - Food and Chemical …, 2004 - Elsevier
This study presents the research on the chemical analysis and genotoxicity of 28
virgin/recycled paper products in food-contact use. In the chemical analysis, paper products …

Detection of DNA damage in haemocytes of zebra mussel using comet assay

M Pavlica, GIV Klobučar, N Mojaš, R Erben… - … /Genetic Toxicology and …, 2001 - Elsevier
The aim of the study was to use the comet assay on haemocytes of freshwater mussel,
Dreissena polymorpha Pallas, for detection of possible DNA damage after exposure to …

Validation of Drosophila melanogaster as an in vivo model for genotoxicity assessment using modified alkaline Comet assay

HR Siddique, DK Chowdhuri, DK Saxena… - Mutagenesis, 2005 - academic.oup.com
The single cell gel electrophoresis or Comet assay is one of the most popular techniques for
genotoxicity assessment. The present study was undertaken to validate our previously …

The DNA of annexin V-binding apoptotic cells is highly fragmented

Z Bacsó, RB Everson, JF Eliason - Cancer Research, 2000 - AACR
Jurkat leukemia cells induced to undergo apoptosis by treatment with an antibody against
the Fas receptor have two annexin V (AV)-binding subpopulations:(a) single-positive cells …

The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats

HO El Mesallamy, NS Metwally, MS Soliman… - Cancer cell …, 2011 - Springer
Background/objective This study was designed to evaluate the potential chemopreventive
activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against …