Roles of chitinase 3-like 1 in the development of cancer, neurodegenerative diseases, and inflammatory diseases

IJ Yeo, CK Lee, SB Han, J Yun, JT Hong - Pharmacology & therapeutics, 2019 - Elsevier
Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression

JE Yu, SH Jeon, MJ Kim, DH Kim… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Chitinase‐3‐like 1 (CHI3L1) causes skin inflammation in
the progression of atopic dermatitis. We investigated if anti‐CHI3L1 antibody could prevent …

Lysophosphatidic acid: Its role in bone cell biology and potential for use in bone regeneration

X Wu, Y Ma, N Su, J Shen, H Zhang, H Wang - Prostaglandins & other lipid …, 2019 - Elsevier
Lysophosphatidic acid (LPA) is a simple phospholipid that exerts pleiotropic effects on
numerous cell types by activating its family of cognate G protein-coupled receptors (GPCRs) …

Ternary nanocomposite potentiates the lysophosphatidic acid effect on human osteoblast (MG63) maturation

H Elkhenany, MA Elkodous, JP Mansell - Nanomedicine, 2023 - Taylor & Francis
Aim: This study aimed to investigate the potential of ternary nanocomposite (TNC) to support
MG63 osteoblast maturation to EB1089-(3S) 1-fluoro-3-hydroxy-4-(oleoyloxy) butyl-1 …

Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis

M Neighbors, Q Li, SJ Zhu, J Liu, WR Wong, G Jia… - Journal of Lipid …, 2023 - ASBMB
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality.
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …

Polydopamine-lysophosphatidate-functionalised titanium: A novel hybrid surface finish for bone regenerative applications

F Baldwin, TJ Craig, AI Shiel, T Cox, K Lee, JP Mansell - Molecules, 2020 - mdpi.com
Aseptic loosening of total joint replacements (TJRs) continues to be the main cause of
implant failures. The socioeconomic impact of surgical revisions is hugely significant; in the …

[HTML][HTML] Development of a facile fluorophosphonate-functionalised titanium surface for potential orthopaedic applications

AI Shiel, WN Ayre, AW Blom, KR Hallam… - Journal of Orthopaedic …, 2020 - Elsevier
Abstracts Background Aseptic loosening of total joint replacements (TJRs) continues to be
the main cause of implant failures. The socioeconomic impact of surgical revisions is hugely …

[HTML][HTML] The evolutionarily conserved cassette exon 7b drives ERG's oncogenic properties

SL Jumbe, SR Porazinski, S Oltean, JP Mansell… - Translational …, 2019 - Elsevier
The oncogene ERG encodes an ETS family transcription factor and is implicated in blood,
vascular, and bone development and in prostate, blood, and bone cancer. The ERG gene is …

[PDF][PDF] Association between bone remodeling and inflammatory markers in obstructive sleep apnea in relation to disease severity

B Bromińska, E Cyrańska-Chyrek… - Pol Arch Intern …, 2018 - scholar.archive.org
ABSTRACT INTRODUCTION There is growing evidence that obstructive sleep apnea (OSA)
influences both bone metabolism and structure. Chitinase‑3‑like protein 1 (YKL‑40) is a …

Alkaline phosphatase binds tenaciously to titanium; implications for biological surface evaluation following bone implant retrieval

JP Mansell, AI Shiel, C Harwood, D Stephens - Materials Science and …, 2017 - Elsevier
Enhancing the performance and longevity of titanium (Ti) implants continues to be a
significant developmental theme in contemporary biomaterials design. Our specific focus …