Interferons (IFNs) manifest their cellular functions by regulating expression of target genes
known collectively as IFN-stimulated genes (ISGs). The repertoires of ISGs vary slightly …

IFNs were the first new therapeutic products resulting from recombinant DNA technology.
IFNs were also the first human proteins effective in cancer treatment. There is however much …

PURPOSE: Retinoids and interferons (IFNs) have single-agent and synergistic combined
effects in modulating cell proliferation, differentiation, and apoptosis in vitro and clinical …

Retinoic acid (RA) and interferons (IFNs) are negative regulators of cell proliferation. In vitro
and in vivo, their combination leads to a more potent growth inhibition. However, the …

Interferons (IFNs) were first characterized as antiviral proteins. Since then, IFNs have proved
to be involved in malignant, angiogenic, inflammatory, immune, and fibrous diseases and …

Retinoic acid (RA) and interferon (IFN) potentiate each other to induce biological responses.
Their combination has shown synergistic differentiating, antiproliferative and antiviral …

Cytokines and vitamins play a central role in controlling neoplastic cell growth. The
interferon (IFN) family of cytokines regulates antiviral, anti-tumor, antimicrobial …

BACKGROUND: For nearly 2 decades clinicians have been treating cutaneous T-cell
lymphoma (CTCL) with regimens that combine interferon alfa with retinoid compounds. In …

In recent years, the effects of cancer chemotherapy and radiotherapy (CT/RT) regimens as
they apply to the immune system have been explored. NK cells represent the main cytotoxic …

Retinoids are vitamin A derivatives that critically regulate several physiological and
pathological processes, including immune functions and cancer development. These …