The burden and risks of emerging complications of diabetes mellitus

D Tomic, JE Shaw, DJ Magliano - Nature Reviews Endocrinology, 2022 - nature.com
The traditional complications of diabetes mellitus are well known and continue to pose a
considerable burden on millions of people living with diabetes mellitus. However, advances …

Diabetes, obesity, and cancer—pathophysiology and clinical implications

IC Lega, LL Lipscombe - Endocrine reviews, 2020 - academic.oup.com
Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

The obesity paradox in cancer: a review

H Lennon, M Sperrin, E Badrick, AG Renehan - Current oncology reports, 2016 - Springer
There is a common perception that excess adiposity, commonly approximated by body mass
index (BMI), is associated with reduced cancer survival. A number of studies have emerged …

Obesity and diabetes: the increased risk of cancer and cancer-related mortality

EJ Gallagher, D LeRoith - Physiological reviews, 2015 - journals.physiology.org
Obesity and type 2 diabetes are becoming increasingly prevalent worldwide, and both are
associated with an increased incidence and mortality from many cancers. The metabolic …

Gastrointestinal consequences of type 2 diabetes mellitus and impaired glycemic homeostasis: a mendelian randomization study

J Chen, S Yuan, T Fu, X Ruan, J Qiao, X Wang… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the
associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs) …

Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation

JL Harding, JE Shaw, A Peeters, B Cartensen… - Diabetes …, 2015 - Am Diabetes Assoc
OBJECTIVE Evidence indicates an increased risk of certain cancers among people with type
2 diabetes. Evidence for rarer cancers and for type 1 diabetes is limited. We explored the …

[HTML][HTML] Type 2 diabetes mellitus and risk of hepatocellular carcinoma: spotlight on nonalcoholic fatty liver disease

A Mantovani, G Targher - Annals of translational medicine, 2017 - ncbi.nlm.nih.gov
The incidence of both type 2 diabetes mellitus (T2DM) and multiple cancer types are rapidly
increasing worldwide. Several studies documented that T2DM is closely associated with an …

Is type 2 diabetes causally associated with cancer risk? Evidence from a two-sample Mendelian randomization study

S Yuan, S Kar, P Carter, M Vithayathil, AM Mason… - Diabetes, 2020 - Am Diabetes Assoc
We conducted a two-sample Mendelian randomization study to investigate the causal
associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site …

Association of diabetes mellitus and pancreatic adenocarcinoma: a meta-analysis of 88 studies

P Batabyal, S Vander Hoorn, C Christophi… - Annals of surgical …, 2014 - Springer
Background Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced,
incurable stage. Previous epidemiological data suggests that diabetes mellitus (DM) is a risk …

Development and prognosis of hepatocellular carcinoma in patients with diabetes

T Nakatsuka, R Tateishi - Clinical and molecular hepatology, 2022 - pmc.ncbi.nlm.nih.gov
The incidence of diabetes mellitus and hepatocellular carcinoma (HCC) has been
increasing worldwide during the last few decades, in the context of an increasing prevalence …