Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Neurobiology of schemas and schema-mediated memory

A Gilboa, H Marlatte - Trends in cognitive sciences, 2017 - cell.com
Schemas are superordinate knowledge structures that reflect abstracted commonalities
across multiple experiences, exerting powerful influences over how events are perceived …

What learning systems do intelligent agents need? Complementary learning systems theory updated

D Kumaran, D Hassabis, JL McClelland - Trends in cognitive sciences, 2016 - cell.com
We update complementary learning systems (CLS) theory, which holds that intelligent
agents must possess two learning systems, instantiated in mammalians in neocortex and …

The hippocampus and related neocortical structures in memory transformation

MJ Sekeres, G Winocur, M Moscovitch - Neuroscience letters, 2018 - Elsevier
Episodic memories are multifaceted and malleable, capable of being transformed with time
and experience at both the neural level and psychological level. At the neural level, episodic …

Complementary learning systems within the hippocampus: a neural network modelling approach to reconciling episodic memory with statistical learning

AC Schapiro, NB Turk-Browne… - … of the Royal …, 2017 - royalsocietypublishing.org
A growing literature suggests that the hippocampus is critical for the rapid extraction of
regularities from the environment. Although this fits with the known role of the hippocampus …

[HTML][HTML] Neuronal computation underlying inferential reasoning in humans and mice

HC Barron, HM Reeve, RS Koolschijn, PV Perestenko… - Cell, 2020 - cell.com
Every day we make decisions critical for adaptation and survival. We repeat actions with
known consequences. But we also draw on loosely related events to infer and imagine the …

[HTML][HTML] Replay and compositional computation

Z Kurth-Nelson, T Behrens, G Wayne, K Miller… - Neuron, 2023 - cell.com
Replay in the brain has been viewed as rehearsal or, more recently, as sampling from a
transition model. Here, we propose a new hypothesis: that replay is able to implement a form …

The role of the hippocampus in flexible cognition and social behavior

RD Rubin, PD Watson, MC Duff… - Frontiers in human …, 2014 - frontiersin.org
Successful behavior requires actively acquiring and representing information about the
environment and people, and manipulating and using those acquired representations …

Memory integration: neural mechanisms and implications for behavior

ML Schlichting, AR Preston - Current opinion in behavioral sciences, 2015 - Elsevier
Highlights•Prior related memories are reactivated during new learning events.•Medial PFC
guides reactivation toward related, goal-relevant knowledge.•Hippocampus compares …

Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex

ML Schlichting, JA Mumford, AR Preston - Nature communications, 2015 - nature.com
The episodic memory system enables accurate retrieval while maintaining flexibility by
representing both specific episodes and generalizations across events. Although theories …