Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

During vertebrate organogenesis, increases in morphological complexity are tightly coupled
to morphogen expression. In this work, we studied how morphogens influence self …

Aggregates of stem cells can break symmetry and self-organize into embryo-like structures
with complex morphologies and gene expression patterns. Mechanisms including reaction …

Here, we review recent developments in the literature that provide insight into self-
organization at supracellular scales in vertebrate organ morphogenesis. We briefly present …

The ability of cells to organize into tissues with proper structure and function requires the
effective coordination of proliferation, migration, polarization, and differentiation across …

Morphogenesis and cell state transitions must be coordinated in time and space to produce
a functional tissue. An excellent paradigm to understand the coupling of these processes is …

Plastic deformation in cells and tissues has been found to play crucial roles in collective cell
migration, cancer metastasis, and morphogenesis. However, the fundamental question of …

With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …

Understanding complex living systems, which are fundamentally constrained by physical
phenomena, requires combining experimental data with theoretical physical and …