Differential modulation of cytochrome P450 enzymes by arsenicals in non-human experimental models

MA El-Ghiaty, SR El-Mahrouk… - Drug Metabolism …, 2023 - Taylor & Francis
Arsenic is a hazardous heavy metalloid that imposes threats to human health globally. It is
widely spread throughout the environment in various forms. Arsenic-based compounds are …

Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes

HU Jeong, SS Kwon, TY Kong, JH Kim… - Journal of Toxicology …, 2014 - Taylor & Francis
Cedrol, β-cedrene, and thujopsene are bioactive sesquiterpenes found in cedar essential oil
and exert antiseptic, anti-inflammatory, antispasmodic, tonic, astringent, diuretic, sedative …

Insecticide chlorpyrifos and fungicide carbendazim, common food contaminants mixture, induce hepatic, renal, and splenic oxidative damage in female rats

AO Abolaji, IO Awogbindin… - Human & …, 2017 - journals.sagepub.com
The fungicide carbendazim (CBZ) and insecticide chlorpyrifos (CPF) are currently applied
together by farmers for the control of pests. Here, we investigated the impacts of 7 days oral …

Evaluation of oxidative stress-mediated cytotoxicity and genotoxicity of copper and flubendiamide: amelioration by antioxidants in vivo and in vitro

R Mandil, A Prakash, A Rahal, S Koli… - Toxicology …, 2023 - academic.oup.com
Present study was designed to evaluate toxic effects of copper (Cu)(@ 33 mg/kg b. wt.) and
flubendimide (Flb)(@ 200 mg/kg b. wt.) alone and/or in combination on blood-biochemical …

A comparative study on subacute toxicity of arsenic trioxide and dimethylarsinic acid on antioxidant status in Crandell Rees feline kidney (CRFK), human …

AC Elia, G Magara, C Caruso, L Masoero… - Journal of Toxicology …, 2018 - Taylor & Francis
Arsenic (As) is a global contaminant of terrestrial and aquatic environments posing concern
for environmental and human health. The effects of subacute concentrations of arsenic …

Nephrotoxic potential and toxicokinetics of melamine combined with cyanuric acid in rats

GH Kim, MJ Kang, K Noh, DG Oh, W Kang… - Journal of Toxicology …, 2014 - Taylor & Francis
To investigate the nephrotoxic potential of melamine (MEL) and cyanuric acid (CA) in male
Sprague-Dawley rats, 7-d repeated-dose studies were performed. The experimental groups …

Directed-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis

H Lee, JH Kim, S Han, YR Lim, HG Park… - Journal of Toxicology …, 2014 - Taylor & Francis
Cytochrome P450 2A6 (P450 2A6) is the major enzyme responsible for the oxidation of
coumarin, nicotine, and tobacco-specific nitrosamines in human liver. In this study, the …

Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocyte.

JUHEE KIM, I KIM - Indian Journal of Pharmaceutical …, 2023 - search.ebscohost.com
As complex mixtures of carcinogenic metalloids, arsenic compounds have been reported to
possess anticytotoxic and antitumor effects. In this study, we evaluated the in vitro protective …

Enantioselective N-Demethylation and Hydroxylation of Sibutramine in Human Liver Microsomes and Recombinant Cytochrome P-450 Isoforms

DD Shinde, MJ Kim, ES Jeong, YW Kim… - Journal of Toxicology …, 2014 - Taylor & Francis
The enantioselective metabolism of sibutramine was examined using human liver
microsomes (HLM) and recombinant cytochrome P-450 (CYP) isoforms. This drug is …

Modulation of Aryl Hydrocarbon Receptor (AHR)-Regulated Metabolic Enzymes by Arsenic Trioxide and its Thioarsenical Metabolite

MAA Elghiaty - 2024 - era.library.ualberta.ca
(APL), however, being an arsenical, it retains at its core the hypertoxic characteristics of that
notorious metalloid. Such inherent toxicity causes a constellation of complications in APL …