Background Chronic pancreatitis (CP) is a complex inflammatory disease with remarkably
impaired quality of life and permanent damage of the pancreas. This paper is part of the …

Currently, among patients with severe hypertriglyceridemia, the most consistent predictor of
pancreatitis risk is the triglyceride level. Furthermore, pancreatitis risk appears to be …

Objective Increasing evidence implicates mutation-induced protein misfolding and
endoplasm reticulum (ER) stress in the pathophysiology of chronic pancreatitis (CP). The …

Inborn mutations in the digestive protease carboxypeptidase A1 (CPA1) gene may be
associated with hereditary and idiopathic chronic pancreatitis (CP). Pathogenic mutations …

Chronic pancreatitis (CP) is a complex disease with genetic and environmental factors at
play. Through trio exome sequencing, a de novo SEC16A frameshift variant in a Chinese …

We read with great interest the recent article by Zhu et al, 1 demonstrating that misfolding of
pancreatic lipase due to an inborn mutation causes chronic pancreatitis (CP). Variants in the …

Regenerating gene family member 4 (Reg4) has been implicated in acute pancreatitis, but
its precise functions and involved mechanisms have remained unclear. Herein, we sought to …

Pancreas serves endocrine and exocrine functions in the body; thus, their pathology can
cause a broad range of irreparable consequences. Endocrine functions include the …

Abstract Background/Objective Mutation-induced misfolding of digestive enzymes has been
shown to cause chronic pancreatitis. Recently, heterozygous pancreatic lipase (PNLIP) …

Abstract Background/Objectives: Sequence variants in several genes have been identified
as being associated with an increased inherited risk to develop chronic pancreatitis (CP). In …