The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

Physiological changes that endow mammalian sperm with fertilizing capacity are known as
sperm capacitation. As part of capacitation, sperm develop an asymmetrical flagellar beating …

Molecular mimicry is an evolutionary strategy adopted by viruses to exploit the host cellular
machinery. We report that SARS-CoV-2 has evolved a unique S1/S2 cleavage site, absent …

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of
ion channels located in the membranes of all cells and many cellular organelles. These …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Abstract Purpose of Review We aim to review the mechanism of action and safety profile of
mineralocorticoid receptor antagonists (MRAs) and discuss the differences between …

Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an
autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline …

Epithelial Na+ channels (ENaCs) are members of a family of cation channels that function as
sensors of the extracellular environment. ENaCs are activated by specific proteases in the …

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene. The resultant characteristic ion transport defect results in decreased …

Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR …