The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

Voltage-dependent potassium ion (K+) channels (Kv channels) conduct K+ ions across the
cell membrane in response to changes in the membrane voltage, thereby regulating …

Pyramidal neurons receive tens of thousands of synaptic inputs on their dendrites. The
dendrites dynamically alter the strengths of these synapses and coordinate them to produce …

Living cells regulate the activity of their ion channels through a process known as gating. To
open the pore, protein conformational changes must occur within a channel's membrane …

The voltage-gated potassium channels are the prototypical members of a family of
membrane signalling proteins. These protein-based machines have pores that pass millions …

Voltage-gated sodium, calcium, and potassium channels generate electrical signals
required for action potential generation and conduction and are the molecular targets for a …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox
transformations involved in biosynthesis, intermediary metabolism, and detoxification …

Episodic ataxia (EA) is a rare, familial disorder producing attacks of generalized ataxia, with
normal or near-normal neurological function between attacks. One type of EA is …