Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy
characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and …

Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening thrombotic
microangiopathy characterized by microangiopathic hemolytic anemia, severe …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Introduction: Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening
thrombotic microangiopathy characterized by microangiopathic hemolytic anemia …

Rationale: PAD4 (peptidylarginine deiminase type IV), an enzyme essential for neutrophil
extracellular trap formation (NETosis), is released together with neutrophil extracellular traps …

Essentials• Conformational changes in ADAMTS‐13 are part of its mode‐of‐action.• The
murine anti‐ADAMTS‐13 antibody 1C4 discriminates between folded and open ADAMTS …

Child‐onset thrombotic thrombocytopenic purpura (TTP) is a rare entity of thrombotic
microangiopathy (TMA). The pathophysiology of the disease is based on a severe functional …

Immune thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder of which
the etiology is not fully understood. Autoantibodies targeting ADAMTS13 in iTTP patients …

Thrombotic thrombocytopenic purpura (TTP) is a fatal disease in which platelet-rich
microthrombi cause end-organ ischemia and damage. TTP is caused by markedly reduced …

Although outstanding progress has been made in understanding the pathophysiology of
thrombotic thrombocytopenic purpura (TTP), knowledge of the immunopathogenesis of the …