Cancer, a common malignant disease, is one of the predominant causes of diseases that
lead to death. Additionally, cancer is often detected in advanced stages and cannot be …

Simple Summary Our understanding of renal tumors has increased in the last years with the
description of several novel entities. The expanding morphological spectrum complicates …

Despite the increasing number of newly identified renal neoplasms, the diagnosis of renal
cell carcinoma (RCC) can usually be reached with careful histologic examination and a …

MiT family translocation renal cell carcinoma (MiT-RCC) harbors translocations involving the
TFE3 or TFEB genes. RCC with TFEB amplification is also identified and is associated with a …

Aims Renal cell carcinomas (RCCs) represent 2–5% of kidney malignancies in children and
adolescents. Appropriate diagnostic and classification are crucial for the correct …

Chromosomal fusions encoding novel molecular drivers have been identified in several
solid tumors, and in recent years the identification of such pathogenetic events in tumor …

TFE3-rearranged renal cell cancer (tRCC) is a rare form of RCC that involves chromosomal
translocation of the Xp11. 2 TFE3 gene. Despite its early onset and poor prognosis, the …

Kidney tumors comprise a broad spectrum of different histopathological entities, with more
than 0.4 million newly diagnosed cases each year, mostly in middle-aged and older men …

TFE3 rearranged Renal cell carcinoma (RCC) is not very common, and demonstrates
unique heterogenous morphological features overlapping other recognized entities and …

In recent years, several emerging diagnostic entities have been described in renal cell
carcinoma (RCC). However, our understanding of well-known and established entities has …