Use of computational fluid dynamics deposition modeling in respiratory drug delivery
Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …
Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs
Prediction of local exposure following inhalation of a locally acting pulmonary drug is central
to the successful development of novel inhaled medicines, as well as generic equivalents …
to the successful development of novel inhaled medicines, as well as generic equivalents …
Bridging the gap between science and clinical efficacy: physiology, imaging, and modeling of aerosols in the lung
Abstract Development of a new drug for the treatment of lung disease is a complex and time
consuming process involving numerous disciplines of basic and applied sciences. During …
consuming process involving numerous disciplines of basic and applied sciences. During …
Recent developments in the computational simulation of dry powder inhalers
J Capecelatro, W Longest, C Boerman… - Advanced Drug Delivery …, 2022 - Elsevier
This article reviews recent developments in computational modeling of dry powder inhalers
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …
(DPIs). DPIs deliver drug formulations (sometimes blended with larger carrier particles) to a …
Scientific and regulatory activities initiated by the US food and drug administration to foster approvals of generic dry powder inhalers: bioequivalence perspective
Regulatory science for generic dry powder inhalers (DPIs) in the United States (US) has
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
evolved over the last decade. In 2013, the US Food and Drug Administration (FDA) …
Prediction of the carrier shape effect on particle transport, interaction and deposition in two dry powder inhalers and a mouth-to-G13 human respiratory system: A CFD …
Documentation of comparability between generic inhaler designs and the reference listed
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …
In Vitro Tests for Aerosol Deposition. VI: Realistic Testing with Different Mouth–Throat Models and In Vitro—In Vivo Correlations for a Dry Powder Inhaler, Metered …
Background: In vitro—in vivo correlations (IVIVC) for lung deposition may be established by
testing inhalers in vitro with realistic mouth–throat (MT) models and inhalation profiles (IP) …
testing inhalers in vitro with realistic mouth–throat (MT) models and inhalation profiles (IP) …
In silico evaluation of particle transport and deposition in the airways of individual patients with chronic obstructive pulmonary disease
K Kadota, K Matsumoto, H Uchiyama, S Tobita… - European Journal of …, 2022 - Elsevier
Inhalation therapy can effectively treat chronic obstructive pulmonary disease (COPD), but
the physical factors determining the appropriate aerosol delivery into the targeted airways …
the physical factors determining the appropriate aerosol delivery into the targeted airways …
In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation
SP Newman, HK Chan - Advanced Drug Delivery Reviews, 2020 - Elsevier
Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …
[HTML][HTML] Additive manufacturing in respiratory sciences–Current applications and future prospects
Additive Manufacturing (AM) comprises a variety of techniques that enable fabrication of
customised objects with specific attributes. The versatility of AM procedures and constant …
customised objects with specific attributes. The versatility of AM procedures and constant …