Periodontal diseases include periodontitis and gingival overgrowth. Periodontitis is a
bacterial infectious disease, and its pathological cascade is regulated by many inflammatory …

Drug-induced gingival overgrowth (DIGO) is one of the side effects produced by therapeutic
agents, most commonly phenytoin, nifedipine and cyclosporin A. However, the precise …

Both skin and oral mucosa are characterized by the presence of keratinized epithelium in
direct apposition to an underlying collagen-dense connective tissue. Despite significant …

Although the matricellular protein periostin is prominently upregulated in skin and gingival
healing, it plays contrasting roles in myofibroblast differentiation and matrix synthesis …

Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins
that are important regulators and integrators of microenvironmental signals, contributing to …

In healthy individuals, the healing of soft tissues such as skin after pathological insult or post
injury follows a relatively predictable and defined series of cell and molecular processes to …

Background: Phenytoin induced gingival overgrowth, a side effect with multifactorial
aetiology, is characterized by an increase in the volume of extracellular tissues, particularly …

Abstract Background and Objective Human gingival fibrolasts aging is an important cause of
periodontal disease. Phenytoin sodium (phenytoin) has a side effect of gingival hyperplasia …

Background Fibrotic responses in the gingiva are characterized by their hyperproliferative
nature instead of scar tissue formation. Clinically, these conditions appear as “gingival …

Abstract Purpose Gingival fibromas (GFs) are fibrous lesions of the gingiva that are not well
defined in the literature. They are histologically similar to peripheral ossifying fibromas …